Apolipoprotein E genotype is not associated with cognitive impairment in older adults with bipolar disorder.

doi:10.1111/bdi.12367

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Article

Apolipoprotein E genotype is not associated with cognitive impairment in older adults with bipolar disorder.

Bipolar disorders - 1 Feb 2016

Kerr Daniel Shikanai, Stella Florindo, Radanovic Márcia, Aprahamian Ivan, Bertollucci Paulo Henrique Ferreira, Forlenza Orestes Vicente

Abstract excerpt

OBJECTIVES: Cognitive decline is part of the long-term outcome for many individuals with bipolar disorder (BD). The ε4 allele (APOE*4) of apolipoprotein E (APOE) is a well-established risk factor for dementia in Alzheimer's disease (AD). However, its contribution to the risk of cognitive deterioration in BD has not yet been determined. Our aim was to analyze the APOE genotype association with cognitive status in...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Bipolar Disorder
Cognition Disorders
Cognitive Dysfunction
Female
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Humans

Male

Neuropsychological Tests

Real-Time Polymerase Chain Reaction

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 26877211
DOI: 10.1111/bdi.12367

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26877211-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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