Article
The apolipoprotein E gene in Binswanger's disease and vascular dementia.
Clinical genetics - 1 Dec 1996
Higuchi S, Arai H, Nakagawa T, Muramatsu T, Sasaki H, Trojanowski J Q
Abstract excerpt
We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the epsilon 4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the nondemented elderly controls, but it was significantly lower than the...
Topics
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Dementia, Vascular
- Disease Susceptibility
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Polymerase Chain Reaction