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Article

HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes.

Oncogene - 8 Sept 2016

Cui J, Xia T, Xie D, Gao Y, Jia Z, Wei D, Wang L, Huang S, Quan M, Xie K

Abstract excerpt

Hepatocyte growth factor (HGF)/Met signaling has critical roles in pancreatic ductal adenocarcinoma (PDA) development and progression and is considered a potential therapeutic target for this disease. However, the mechanism of aberrant activation of HGF/Met signaling and resistance to Met inhibition in PDA remains unclear. The mechanistic role of cross talk between Forkhead box M1 (FOXM1) and HGF/Met signaling in...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Hepatocyte Growth Factor

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins c-met

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Source

Open in PubMed Open full text

Identifiers

PMID: 26876216
DOI: 10.1038/onc.2016.14
PMCID: PMC4985506

Genes

FOXM1
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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