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Article

Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer

1 Feb 2019

Abstract excerpt

Abstract There is compelling evidence that oncogenic MET and PIK3CA signaling pathways contribute to breast cancer. However, the activity of pharmacologic targeting of either pathway is modest. Mechanisms of resistance to these monotherapies have not been clarified. Currently, commonly used mouse models are inadequate for studying the HGF–MET axis because mouse HGF does not bind human MET. We established human...

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PMID: 30518672
DOI: 10.1158/1535-7163.mct-18-0710

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