Article
Individual patient oesophageal cancer 3D models for tailored treatment.
Oncotarget - 11 Apr 2017
Saunders John H, Onion David, Collier Pamela, Dorrington Matthew S, Argent Richard H, Clarke Philip A, Reece-Smith Alex M, Parsons Simon L, Grabowska Anna M
Abstract excerpt
BACKGROUND: A model to predict chemotherapy response would provide a marked clinical benefit, enabling tailored treatment of oesophageal cancer, where less than half of patients respond to the routinely administered chemotherapy. METHODS: Cancer cells were established from tumour biopsies taken from individual patients about to undergo neoadjuvant chemotherapy. A 3D-tumour growth assay (3D-TGA) was developed, in...
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