Article
Codon Usage Selection Can Bias Estimation of the Fraction of Adaptive Amino Acid Fixations.
Molecular biology and evolution - 1 Jun 2016
Matsumoto Tomotaka, John Anoop, Baeza-Centurion Pablo, Li Boyang, Akashi Hiroshi
Abstract excerpt
A growing number of molecular evolutionary studies are estimating the proportion of adaptive amino acid substitutions (α) from comparisons of ratios of polymorphic and fixed DNA mutations. Here, we examine how violations of two of the model assumptions, neutral evolution of synonymous mutations and stationary base composition, affect α estimation. We simulated the evolution of coding sequences assuming weak...
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