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Article

The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells.

Experimental cell research - 10 Apr 2016

Revach Or-Yam, Winograd-Katz Sabina E, Samuels Yardena, Geiger Benjamin

Abstract excerpt

In this article, we discuss the complex involvement of a Rho-family GTPase, Rac1, in cell migration and in invadopodia-mediated matrix degradation. We discuss the involvement of invadopodia in invasive cell migration, and their capacity to promote cancer metastasis. Considering the regulation of invadopodia formation, we describe studies that demonstrate the role of Rac1 in the metastatic process, and the...

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Identifiers

PMID: 26873115
DOI: 10.1016/j.yexcr.2016.02.003
PMCID: PMC4954600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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