Article
DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation.
Biochemical and biophysical research communications - 26 Feb 2018
Tomino Takahiro, Tajiri Hirotada, Tatsuguchi Takaaki, Shirai Takahiro, Oisaki Kounosuke, Matsunaga Shigeki, Sanematsu Fumiyuki, Sakata Daiji, Yoshizumi Tomoharu, Maehara Yoshihiko, Kanai Motomu, Cote Jean-François, Fukui Yoshinori, Uruno Takehito
Abstract excerpt
Rac1 is a member of the Rho family of small GTPases that regulates cytoskeletal reorganization, membrane polarization, cell migration and proliferation. Recently, a self-activating mutation of Rac1, Rac1P29S, has been identified as a recurrent somatic mutation frequently found in sun-exposed melanomas, which possesses increased inherent GDP/GTP exchange activity and cell transforming ability. However, the role of...
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