Unlocking immune responses via mitophagy genes: A dual-pronged strategy against hematologic tumors

Abstract excerpt

Mitophagy plays a complex role in cancer biology, particularly in hematologic malignancies. It can promote tumor survival and drug resistance by removing damaged mitochondria and reducing mitochondrial reactive oxygen species (ROS) or conversely inhibit tumor growth by diminishing cellular energy production. In hematologic cancers, mitophagy has dual regulatory effects: moderate mitophagy facilitates the removal o...

Topics

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• Autophagy in Disease and Therapy
• Epigenetics and DNA Methylation
• Histone Deacetylase Inhibitors Research

Identifiers and source

Literature Corpus work

8cb8938d-3203-5245-9354-ae8a634f3cd6

DOI

10.1016/j.lmd.2025.100085