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Article

Clinical and Molecular Characteristics of NF1 -Mutant Lung Cancer

9 Feb 2016

Abstract excerpt

PURPOSE: NF1 is a tumor suppressor that negatively regulates Ras signaling. NF1 mutations occur in lung cancer, but their clinical significance is unknown. We evaluated clinical and molecular characteristics of NF1 mutant lung cancers with comparison to tumors with KRAS mutations. EXPERIMENTAL DESIGN: Between July 2013 and October 2014, 591 non-small cell lung cancer (NSCLC) tumors underwent targeted...

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PMID: 26861459
DOI: 10.1158/1078-0432.ccr-15-2377

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