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Article

RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2018

Hayashi Takuo, Desmeules Patrice, Smith Roger S, Drilon Alexander, Somwar Romel, Ladanyi Marc

Abstract excerpt

Purpose: Ras-GTPase-activating proteins (RasGAP), notably NF1 and RASA1, mediate negative control of the RAS/MAPK pathway. We evaluated clinical and molecular characteristics of non-small cell lung carcinoma (NSCLC) with RASA1 mutations in comparison with NF1-mutated cases.Experimental Design: Large genomic datasets of NSCLC [MSK-IMPACT dataset at MSKCC (n = 2,004), TCGA combined lung cancer dataset (n = 1,144)]...

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Source

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Identifiers

PMID: 29127119
DOI: 10.1158/1078-0432.CCR-17-2343
PMCID: PMC6440215

Genes

RASA1
EGFR
IMPACT
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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