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Article

Genetic diseases associated with heterotrimeric G proteins.

Trends in pharmacological sciences - 1 May 2006

Weinstein Lee S, Chen Min, Xie Tao, Liu Jie

Abstract excerpt

Heterotrimeric G proteins couple receptors for diverse extracellular signals to effector enzymes or ion channels. Each G protein comprises a specific alpha-subunit and a tightly bound betagamma dimer. Several human disorders that result from genetic G-protein abnormalities involve the imprinted GNAS gene, which encodes Gs alpha, the ubiquitously expressed alpha-subunit that couples receptors to adenylyl cyclase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16600389
DOI: 10.1016/j.tips.2006.03.005

Genes

GNAS
GNAT1
GNAT2
GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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