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Article

Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.

Science signaling - 12 Apr 2016

Marivin Arthur, Leyme Anthony, Parag-Sharma Kshitij, DiGiacomo Vincent, Cheung Anthony Y, Nguyen Lien T, Dominguez Isabel, Garcia-Marcos Mikel

Abstract excerpt

Auriculo-condylar syndrome (ACS), a rare condition that impairs craniofacial development, is caused by mutations in a G protein-coupled receptor (GPCR) signaling pathway. In mice, disruption of signaling by the endothelin type A receptor (ET(A)R), which is mediated by the G protein (heterotrimeric guanine nucleotide-binding protein) subunit Gα(q/11) and subsequently phospholipase C (PLC), impairs neural crest...

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Source

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Identifiers

PMID: 27072656
DOI: 10.1126/scisignal.aad2429
PMCID: PMC4870087

Genes

GNAI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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