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Article

Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.

The Journal of clinical investigation - 1 Feb 2017

Chen Min, Shrestha Yogendra B, Podyma Brandon, Cui Zhenzhong, Naglieri Benedetta, Sun Hui, Ho Thuy, Wilson Eric A, Li Yong-Qi, Gavrilova Oksana, Weinstein Lee S

Abstract excerpt

Gsα, encoded by Gnas, mediates hormone and neurotransmitter receptor-stimulated cAMP generation. Heterozygous Gsα-inactivating mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients, but only when the mutations occur on the maternal allele. This parent-of-origin effect is due to Gsα imprinting in the CNS, although the relevant CNS regions are unknown. We have now shown that mice with a...

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Identifiers

PMID: 27991864
DOI: 10.1172/JCI88622
PMCID: PMC5272175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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