Article
Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis.
PLoS genetics - 1 Jan 2012
Tran Phuoc T, Shroff Emelyn H, Burns Timothy F, Thiyagarajan Saravanan, Das Sandhya T, Zabuawala Tahera, Chen Joy, Cho Yoon-Jae, Luong Richard, Tamayo Pablo, Salih Tarek, Aziz Khaled, Adam Stacey J, Vicent Silvestre, Nielsen Carsten H, Withofs Nadia, Sweet-Cordero Alejandro, Gambhir Sanjiv S, Rudin Charles M, Felsher Dean W
Abstract excerpt
KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in both a novel transgenic mutant Kras lung cancer mouse model and in human lung tumors that the inhibition of Twist1 restores a senescence program inducing the loss of...
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