Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization

21 May 2018

Abstract excerpt

Purpose: Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. Eye manifestations are common in NF1 with recent reports describing a vascular dysplasia in the retina and choroid. Common features of NF1 retinopathy include tortuous and dilated feeder vessels that terminate in capillary tufts, increased endothelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Meningioma and schwannoma management
Share to Neurofibromatosis and Schwannoma Cases
Share to Tuberous Sclerosis Complex Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29847659
DOI: 10.1167/iovs.17-22588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal NeovascularizationPMID 29847659Read ↗

Loss of NF1 Expression in Human Endothelial Cells Promotes Autonomous Proliferation and Altered Vascular MorphogenesisSemantic proximity Read ↗

Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathwaySemantic proximity Read ↗

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.Semantic proximity Read ↗

Restoring compromised Blood-Retina-Barrier integrity with Netrin-1 overexpressionSemantic proximity Read ↗

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cellsSemantic proximity Read ↗

Atypical p38 Kinase Signaling in Retinal Vascular Damage and RecoverySemantic proximity Read ↗

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammationSemantic proximity Read ↗

Induced Expression ofVEGFC,ANGPT, andEFNB2and Their Receptors Characterizes Neovascularization in Proliferative Diabetic RetinopathySemantic proximity Read ↗

Loss of Neurofibromin Induces Inflammatory Macrophage Phenotypic Switch and Retinal Neovascularization via GLUT1 ActivationSemantic proximity Read ↗

Transcriptional Comparison of Human and Murine Retinal NeovascularizationSemantic proximity Read ↗

Role of the Norrie Disease Pseudoglioma Gene in Sprouting Angiogenesis during Development of the Retinal VasculatureSemantic proximity Read ↗

MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.