Article
Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.
Pharmacogenetics and genomics - 1 Sept 2009
Hsiao Dun-Jen, Wu Lawrence Shih-Hsin, Huang Shih-Yi, Lin Eugene
Abstract excerpt
The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese...
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