Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational biology approach to identify causative factors for rare toxicities in humans and animals.

Current drug discovery technologies - 1 Mar 2012

Johnson E Dale, Sudarsanam Sucha, Bingham Jonathan, Srinivasan Subha

Abstract excerpt

Genome-wide RNA splicing (with gene expression) can be used to discover variations that drive specific diseases and / or change the susceptibility in individuals to drug responses including tissue specific toxicities. Evidence linking causative SNPs to individual splicing differences between individuals is emerging and this may lead to a better understanding of susceptibilities related to rare drug-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug-Related Side Effects and Adverse Reactions

Share to Expressed Sequence Tags

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genomics

Share to Translational Research, Biomedical

Source

Identifiers

PMID: 22023257
DOI: 10.2174/157016312799304561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational biology approach to identify causative factors for rare toxicities in humans and animals.PMID 22023257Read ↗

Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.Semantic proximity Read ↗

Alternative Splicing in the Nuclear Receptor Superfamily Expands Gene Function to Refine Endo-Xenobiotic Metabolism.Semantic proximity Read ↗

Differential splicing, disease and drug targets.Semantic proximity Read ↗

The ABCs of human alternative splicing: a review of ATP-binding cassette transporter splicing.Semantic proximity Read ↗

The relevance of alternative RNA splicing to pharmacogenomics.Semantic proximity Read ↗

mRNA transcript diversity creates new opportunities for pharmacological intervention.Semantic proximity Read ↗

Toxicogenomics and clinical toxicology: an example of the connection between basic and applied sciences.Semantic proximity Read ↗

Genomics: implications for toxicology.Semantic proximity Read ↗

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism.Semantic proximity Read ↗

Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.Semantic proximity Read ↗

In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists.Semantic proximity Read ↗

Translational Safety Genetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.