Article
Expression of Two Classes of Pax6 Transcripts in Reprogramming Retinal Pigment Epithelium Cells of the Adult Newt.
Zoological science - 1 Feb 2016
Inami Wataru, Islam Md Rafiqul, Nakamura Kenta, Yoshikawa Taro, Yasumuro Hirofumi, Casco-Robles Martin Miguel, Toyama Fubito, Maruo Fumiaki, Chiba Chikafumi
Abstract excerpt
The adult newt has the remarkable ability to regenerate a functional retina from retinal pigment epithelium (RPE) cells, even when the neural retina (NR) is completely lost from the eye. In this system, RPE cells are reprogrammed into a unique state of multipotent cells, named RPESCs, in an early phase of retinal regeneration. However, the signals that trigger reprogramming remain unknown. Here, to approach this...
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