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The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration

13 Aug 2014

Abstract excerpt

The reprogramming of retinal pigment epithelium (RPE) cells in the adult newt immediately after retinal injury is an area of active research for the study of retinal disorders and regeneration. We demonstrate here that unlike embryonic/larval retinal regeneration, adult newt RPE cells are not directly reprogrammed into retinal stem/progenitor cells; instead, they are programmed into a unique state of multipotency...

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PMID: 25116407
DOI: 10.1038/srep06043

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