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Article

GCMa Regulates the Syncytin-mediated Trophoblastic Fusion

1 Dec 2002

Abstract excerpt

The human placental trophoblast cell can be classified as either a cytotrophoblast or a syncytiotrophoblast. Cytotrophoblasts can function as stem cells for the development of the syncytiotrophoblast layer via cell fusion. An envelope gene of the human endogenous retrovirus family W (HERV-W) called syncytin is specifically expressed in the syncytiotrophoblast layer. Syncytin is a fusogenic membrane protein;...

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PMID: 12397062
DOI: 10.1074/jbc.m209316200

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GCMa Regulates the Syncytin-mediated Trophoblastic FusionPMID 12397062Read ↗

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Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its actionSemantic proximity Read ↗

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The proprotein convertase furin is required for trophoblast syncytializationSemantic proximity Read ↗

Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placentaSemantic proximity Read ↗

TFEB controls syncytiotrophoblast differentiationSemantic proximity Read ↗

Trophoblast Cell Fusion and Differentiation Are Mediated by Both the Protein Kinase C and A PathwaysSemantic proximity Read ↗

Endogenous retroviral syncytin: compilation of experimental research on syncytin and its possible role in normal and disturbed human placentogenesisSemantic proximity Read ↗

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The Role of Syncytin in Placental Angiogenesis and Fetal GrowthSemantic proximity Read ↗

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