<i>BRCA1</i> and <i>BRCA2</i> mutations in ovarian cancer patients from China: ethnic‐related mutations in <i>BRCA1</i> associated with an increased risk of ovarian cancer

Abstract excerpt

BRCA1/2 are cancer predisposition genes involved in hereditary breast and ovarian cancer (HBOC). Mutation carriers display an increased sensitivity to inhibitors of poly(ADP-ribose) polymerase (PARP). Despite a number of small-size hospital-based studies being previously reported, there is not yet, to our knowledge, precise data of BRCA1/2 mutations among Chinese ovarian cancer patients. We performed a...