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Article

Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.

The Journal of biological chemistry - 11 Jul 2008

Giudici Camilla, Raynal Nicolas, Wiedemann Hanna, Cabral Wayne A, Marini Joan C, Timpl Rupert, Bächinger Hans Peter, Farndale Richard W, Sasaki Takako, Tenni Ruggero

Abstract excerpt

The 33-kDa matrix protein SPARC (BM-40, osteonectin) binds several collagen types with moderate affinity. The collagen-binding site resides in helix alphaA of the extracellular calcium-binding domain of SPARC and is partially masked by helix alphaC. Previously, we found that the removal of helix alphaC caused a 10-fold increase in the affinity of SPARC for collagen, and we identified amino acids crucial for...

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Identifiers

PMID: 18487610
DOI: 10.1074/jbc.M710001200
PMCID: PMC2443679

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.PMID 18487610Read ↗

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