Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.

doi:10.1158/1078-0432.CCR-15-1434

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Article

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2016

Lou Yanyan, Diao Lixia, Cuentas Edwin Roger Parra, Denning Warren L, Chen Limo, Fan You Hong, Byers Lauren A, Wang Jing, Papadimitrakopoulou Vassiliki A, Behrens Carmen, Rodriguez Jaime Canales, Hwu Patrick, Wistuba Ignacio I, Heymach John V, Gibbons Don L

Abstract excerpt

PURPOSE: Promising results in the treatment of non-small cell lung cancer (NSCLC) have been seen with agents targeting immune checkpoints, such as programmed cell death 1 (PD-1) or programmed death ligand-1 (PD-L1). However, only a select group of patients respond to these interventions. The identification of biomarkers that predict clinical benefit to immune checkpoint blockade is critical to successful clinical...

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PMID: 26851185
DOI: 10.1158/1078-0432.CCR-15-1434
PMCID: PMC4947453

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