A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition.

doi:10.1158/1078-0432.CCR-15-0876

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Article

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2016

Mak Milena P, Tong Pan, Diao Lixia, Cardnell Robert J, Gibbons Don L, William William N, Skoulidis Ferdinandos, Parra Edwin R, Rodriguez-Canales Jaime, Wistuba Ignacio I, Heymach John V, Weinstein John N, Coombes Kevin R, Wang Jing, Byers Lauren Averett

Abstract excerpt

PURPOSE: We previously demonstrated the association between epithelial-to-mesenchymal transition (EMT) and drug response in lung cancer using an EMT signature derived in cancer cell lines. Given the contribution of tumor microenvironments to EMT, we extended our investigation of EMT to patient tumors from 11 cancer types to develop a pan-cancer EMT signature. EXPERIMENTAL DESIGN: Using the pan-cancer EMT...

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Identifiers

PMID: 26420858
DOI: 10.1158/1078-0432.CCR-15-0876
PMCID: PMC4737991

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CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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