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Article

Forward genetic analysis to identify determinants of dopamine signaling in Caenorhabditis elegans using swimming-induced paralysis.

G3 (Bethesda, Md.) - 1 Aug 2012

Hardaway J Andrew, Hardie Shannon L, Whitaker Sarah M, Baas Sarah R, Zhang Bing, Bermingham Daniel P, Lichtenstein Ariana J, Blakely Randy D

Abstract excerpt

Disrupted dopamine (DA) signaling is believed to contribute to the core features of multiple neuropsychiatric and neurodegenerative disorders. Essential features of DA neurotransmission are conserved in the nematode Caenorhabditis elegans, providing us with an opportunity to implement forward genetic approaches that may reveal novel, in vivo regulators of DA signaling. Previously, we identified a robust...

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Identifiers

PMID: 22908044
DOI: 10.1534/g3.112.003533
PMCID: PMC3411251

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