Article
Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations.
Molecular cell - 4 Feb 2016
Buhr Florian, Jha Sujata, Thommen Michael, Mittelstaet Joerg, Kutz Felicitas, Schwalbe Harald, Rodnina Marina V, Komar Anton A
Abstract excerpt
In all genomes, most amino acids are encoded by more than one codon. Synonymous codons can modulate protein production and folding, but the mechanism connecting codon usage to protein homeostasis is not known. Here we show that synonymous codon variants in the gene encoding gamma-B crystallin, a mammalian eye-lens protein, modulate the rates of translation and cotranslational folding of protein domains monitored...
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