Article

Synonymous coding significantly affects the domain swapping propensity of myoglobin

2026-04-06

Abstract excerpt

Co-translational folding is a critical, yet poorly understood, aspect of protein biogenesis due to its transient, heterogeneous, and experimentally inaccessible nature. Using a myoglobin variant engineered towards increased domain swapping, we show that stable dimers formed during heterologous E. Coli expression revert to the monomeric state following denaturation - renaturation and that domain swapping propensity...

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Literature Corpus work: 1d10e9e0-f575-5681-bf32-cc61521429f2
DOI: 10.64898/2026.04.02.716112

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