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Article

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype.

The Journal of clinical investigation - 1 Nov 2012

Tiozzo Caterina, Carraro Gianni, Al Alam Denise, Baptista Sheryl, Danopoulos Soula, Li Aimin, Lavarreda-Pearce Maria, Li Changgong, De Langhe Stijn, Chan Belinda, Borok Zea, Bellusci Saverio, Minoo Parviz

Abstract excerpt

Alveolar capillary dysplasia (ACD) is a congenital, lethal disorder of the pulmonary vasculature. Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encodes a lipid phosphatase controlling key cellular functions, including stem/progenitor cell proliferation and differentiation; however, the role of PTEN in mesodermal lung cell lineage formation remains unexamined. To determine the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23023706
DOI: 10.1172/JCI61334
PMCID: PMC3484434

Genes

ACD
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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