Article
Polymorphism on chromosome 9p21.3 contributes to early-onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients.
Chinese medical journal - 1 Jan 2011
Wang Wei, Peng Wen-Hui, Lu Lin, Zhang Rui-Yan, Zhang Qi, Wang Ling-Jie, Chen Qiu-Jing, Shen Wei-Feng
Abstract excerpt
BACKGROUND: Susceptibility to coronary artery disease (CAD) and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and without type 2 diabetes, and to determine the possible impact of rs1333049 on glucose metabolism and...
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