Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in the long-term consequences of diabetes mellitus.

Abstract excerpt

Diabetes mellitus is the most common metabolic disease, and has late complications that are due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for cell damage in diabetes. Variable functional capacity of detoxifying systems could contribute to differing susceptibility to the...

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