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Influenza A virus PB1-F2 protein: An ambivalent innate immune modulator and virulence factor

23 Apr 2020

Abstract excerpt

Influenza A virus (IAV) causes not only seasonal respiratory illness, but also outbreaks of more severe disease and pandemics when novel strains emerge as a result of reassortment or interspecies transmission. PB1-F2 is an IAV protein expressed from the second open reading frame of PB1 gene. Small as it is, PB1-F2 is a critical virulence factor. Multiple key amino acid residues and motifs of PB1-F2 have been...

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PMID: 32323899
DOI: 10.1002/jlb.4mr0320-206r

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