Article
Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase.
Nature communications - 3 Feb 2016
Kristjansson Ragnar P, Oddsson Asmundur, Helgason Hannes, Sveinbjornsson Gardar, Arnadottir Gudny A, Jensson Brynjar O, Jonasdottir Aslaug, Jonasdottir Adalbjorg, Bragi Walters G, Sulem Gerald, Oskarsdottir Arna, Benonisdottir Stefania, Davidsson Olafur B, Masson Gisli, Magnusson Olafur Th, Holm Hilma, Sigurdardottir Olof, Jonsdottir Ingileif, Eyjolfsson Gudmundur I, Olafsson Isleifur, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Sulem Patrick, Stefansson Kari
Abstract excerpt
Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK and LDH, 28.3 million sequence variants identified through whole-genome sequencing of 2,636 Icelanders were imputed into 63,159 and 98,585 people with CK and LDH measurements, respectively. Here we describe 13 variants associating with serum CK and 16 with...
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