Article

GWAS of serum ALT and AST reveals an association of <i>SLC30A10</i> Thr95Ile with hypermanganesemia symptoms

2020-05-20

Abstract excerpt

To investigate mechanisms of hepatocellular damage, we performed genome-wide association studies (GWAS) on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities across 411,048 subjects from four ancestry groups in the UK Biobank, and found 100 loci associating with both enzymes. The rare missense variant SLC30A10 Thr95Ile (rs188273166) associates with a larger elevation in ALT and A...

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Literature Corpus work: b7d72bbd-529a-5fa7-ba03-cb8a08df0119
DOI: 10.1101/2020.05.19.104570

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