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Article

Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.

EBioMedicine - 1 May 2026

Chen Gang, Zhao Sizheng S, Chinoy Hector, Lilleker James B, Liu Weijie, Li Yuhui, Morris Andrew P, Lamb Janine A

Abstract excerpt

BACKGROUND: Serum creatine kinase (CK) is a routinely measured biomarker of muscle damage, yet the genetic factors underlying inter-individual variation in CK levels remain poorly defined. METHODS: Here we present a large multi-ancestry genome-wide association meta-analysis of serum CK, comprising 237,255 participants spanning Admixed American, African American, East Asian, European and Middle Eastern...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42066438
DOI: 10.1016/j.ebiom.2026.106274
PMCID: PMC13142019

Genes

KLF5
SMAD3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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