Article
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.
Nature communications - 27 Jul 2021
Ward Lucas D, Tu Ho-Chou, Quenneville Chelsea B, Tsour Shira, Flynn-Carroll Alexander O, Parker Margaret M, Deaton Aimee M, Haslett Patrick A J, Lotta Luca A, Verweij Niek, Ferreira Manuel A R, Baras Aris, Hinkle Gregory, Nioi Paul
Abstract excerpt
Understanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities have proven useful for investigating liver biology. Here we report 100 loci associating with both enzymes, using GWAS across 411,048 subjects in the UK Biobank. The rare missense variant...
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