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Article

Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse.

Biochemical and biophysical research communications - 24 Nov 2006

Nishida Yoichiro, Yokota Takanori, Takahashi Tsubura, Uchihara Toshiki, Jishage Kou-ichi, Mizusawa Hidehiro

Abstract excerpt

Increased oxidative damage is a prominent and early feature in Alzheimer disease (AD). However, whether it is a primary cause or merely a downstream consequence in AD pathology is still unknown. We previously generated alpha-tocopherol transfer protein knockout (Ttpa-/-) mice, in which lipid peroxidation in the brain was significantly increased by complete depletion of alpha-tocopherol (alpha-Toc). Here we...

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PMID: 17026966
DOI: 10.1016/j.bbrc.2006.09.083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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