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Article

Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice.

Neurobiology of disease - 1 Feb 2005

Schuessel Katrin, Schäfer Stephanie, Bayer Thomas A, Czech Christian, Pradier Laurent, Müller-Spahn Franz, Müller Walter E, Eckert Anne

Abstract excerpt

Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease. To determine which mechanisms cause the origin of oxidative damage, we analyzed enzymatic antioxidant defense (Cu/Zn-superoxide dismutase Cu/Zn-SOD, glutathione peroxidase GPx and glutathione reductase GR) and lipid peroxidation products malondialdehyde MDA and 4-hydroxynonenal HNE in two different APP transgenic mouse models at...

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Source

Identifiers

PMID: 15649699
DOI: 10.1016/j.nbd.2004.09.003

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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