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Article

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison

14 Jan 2016

Abstract excerpt

Mutations in Nav1.4 and Nav1.5 α-subunits have been associated with muscular and cardiac channelopathies, respectively. Despite intense research on the structure and function of these channels, a lot of information is still missing to delineate the various physiological and pathophysiological processes underlying their activity at the molecular level. Nav1.4 and Nav1.5 sequences are similar, suggesting structural...

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PMID: 26834636
DOI: 10.3389/fphar.2015.00314

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