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Article

Proteins and domains vary in their tolerance of non-synonymous single nucleotide polymorphisms (nsSNPs).

Journal of molecular biology - 26 Apr 2013

Yates Christopher M, Sternberg Michael J E

Abstract excerpt

The widespread application of whole-genome sequencing is identifying numerous non-synonymous single nucleotide polymorphisms (nsSNPs), many of which are associated with disease. We analyzed nsSNPs from Humsavar and the 1000 Genomes Project to investigate why some proteins and domains are more tolerant of mutations than others. We identified 311 proteins and 112 Pfam families, corresponding to 2910 domains, as...

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Identifiers

PMID: 23357174
DOI: 10.1016/j.jmb.2013.01.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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