SNPdryad: predicting deleterious non-synonymous human SNPs using only orthologous protein sequences.

doi:10.1093/bioinformatics/btt769

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Article

SNPdryad: predicting deleterious non-synonymous human SNPs using only orthologous protein sequences.

Bioinformatics (Oxford, England) - 15 Apr 2014

Wong Ka-Chun, Zhang Zhaolei

Abstract excerpt

MOTIVATION: The recent advances in genome sequencing have revealed an abundance of non-synonymous polymorphisms among human individuals; subsequently, it is of immense interest and importance to predict whether such substitutions are functional neutral or have deleterious effects. The accuracy of such prediction algorithms depends on the quality of the multiple-sequence alignment, which is used to infer how an...

Topics

Algorithms
Amino Acid Sequence
Amino Acid Substitution
Chromosome Mapping
Computational Biology
Humans
Polymorphism, Single Nucleotide
Proteome
Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 24389653
DOI: 10.1093/bioinformatics/btt769

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