Article

Epigenetic Regulation of Human Sirtuin 1 Insights into Aging Mechanisms

2024-10-08

Abstract excerpt

Sirtuin 1 (SIRT1), a member of the NAD+-dependent deacetylases, plays a pivotal role in epigenetic regulation related to aging. As the most extensively studied sirtuin, SIRT1 influences numerous cellular processes including metabolism, DNA repair, and cell survival, by deacetylating both histone and non-histone proteins. Epigenetic modifications in SIRT1, such as DNA methylation and post-translational histone modi...

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Literature Corpus work: 81edf4cb-d0aa-527e-a98b-020e521f5e65
DOI: 10.20944/preprints202410.0596.v1

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