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Article

Polymerase specific error rates and profiles identified by single molecule sequencing.

Mutation research - 1 Jan 2000

Hestand Matthew S, Van Houdt Jeroen, Cristofoli Francesca, Vermeesch Joris R

Abstract excerpt

DNA polymerases have an innate error rate which is polymerase and DNA context specific. Historically the mutational rate and profiles have been measured using a variety of methods, each with their own technical limitations. Here we used the unique properties of single molecule sequencing to evaluate the mutational rate and profiles of six DNA polymerases at the sequence level. In addition to accurately...

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Identifiers

PMID: 26829216
DOI: 10.1016/j.mrfmmm.2016.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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