Article
Effects of the SLCO1B1 *1 and SLCO1B1 *5 polymorphisms on IL-6 and IL-10 levels in patients under pravastatin treatment prior to inguinal hernia repair.
International journal of surgery (London, England) - 1 Mar 2016
Cárdenas-Rojas Martha Irazema, Delgado-Enciso Ivan, Baltazar-Rodríguez Luz Margarita, Guzmán-Esquivel José, Ramírez-Flores Mario
Abstract excerpt
BACKGROUND: Different genetic variants in the SLCO1B1 gene have been shown to have functional importance in individual variability in pravastatin pharmacokinetics, resulting in different inflammatory responses to surgical inguinal hernia repair. The aim of this study was to determine IL-6 and IL-10 serum concentrations in the presence and absence of the SLCO1B1*1 and SLCO1B1*5 polymorphisms in patients under...
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