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Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

3 May 2013

Abstract excerpt

Heterogeneous microenvironmental conditions play critical roles in cancer pathogenesis and therapy resistance and arise from changes in tissue dimensionality, cell-extracellular matrix (ECM) interactions, soluble factor signaling, oxygen as well as metabolic gradients, and exogeneous biomechanical cues. Traditional cell culture approaches are restricted in their ability to mimic this complexity with physiological...

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PMID: 23642249
DOI: 10.1146/annurev-bioeng-071811-150028

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