Article
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
Nature genetics - 1 Sept 2005
Meetei Amom Ruhikanta, Medhurst Annette L, Ling Chen, Xue Yutong, Singh Thiyam Ramsing, Bier Patrick, Steltenpool Jurgen, Stone Stacie, Dokal Inderjeet, Mathew Christopher G, Hoatlin Maureen, Joenje Hans, de Winter Johan P, Wang Weidong
Abstract excerpt
Fanconi anemia is a genetic disease characterized by genomic instability and cancer predisposition. Nine genes involved in Fanconi anemia have been identified; their products participate in a DNA damage-response network involving BRCA1 and BRCA2 (refs. 2,3). We previously purified a Fanconi anemia core complex containing the FANCL ubiquitin ligase and six other Fanconi anemia-associated proteins. Each protein in...
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