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The C-terminal region of Trypanosoma cruzi MASPs is antigenic and secreted via exovesicles

8 Jun 2016

Abstract excerpt

Trypanosoma cruzi is the etiological agent of Chagas disease, a neglected and emerging tropical disease, endemic to South America and present in non-endemic regions due to human migration. The MASP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a key role in immune evasion. A common feature of MASPs is the presence of two conserved regions: an N-terminal region...

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PMID: 27270330
DOI: 10.1038/srep27293

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