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Article

The Effect of the Canine ABCB1-1Δ Mutation on Sedation after Intravenous Administration of Acepromazine.

Journal of veterinary internal medicine - 1 Jan 2000

Deshpande D, Hill K E, Mealey K L, Chambers J P, Gieseg M A

Abstract excerpt

BACKGROUND: Dog breeds with the ABCB1-1Δ mutation have substantially truncated nonfunctional P-glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine. Anecdotal reports suggested ABCB1 mut/mut dogs showed increased depth and duration of acepromazine sedation. HYPOTHESIS/OBJECTIVES: That ABCB1 mut/mut dogs have increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Source

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Identifiers

PMID: 26822006
DOI: 10.1111/jvim.13827
PMCID: PMC4913601

Genes

ABCB1

Provenance

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