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Article

Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene.

American journal of veterinary research - 1 Sept 2012

Orzechowski Krystyna L, Swain Marla D, Robl Martin G, Tinaza Constante A, Swaim Heidi L, Jones Yolanda L, Myers Michael J, Yancy Haile F

Abstract excerpt

OBJECTIVE: To develop in genetically engineered mice an alternative screening method for evaluation of P-glycoprotein substrate toxicosis in ivermectin-sensitive Collies. ANIMALS: 14 wild-type C57BL/6J mice (controls) and 21 genetically engineered mice in which the abcb1a and abcb1b genes were disrupted and the mutated canine ABCB1 gene was inserted. PROCEDURES: Mice were allocated to receive 10 mg of...

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Source

Identifiers

PMID: 22924731
DOI: 10.2460/ajvr.73.9.1477

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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