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Article

Safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) in homozygous MDR1-mutant collie dogs.

Parasites & vectors - 23 Apr 2025

Riggs Kari L, Wang Xinshuo, Wiseman Scott

Abstract excerpt

BACKGROUND: Multidrug resistance-1 (MDR1) mutant dogs have diminished or lack P-glycoprotein (Pgp) expression at the blood-brain barrier and are therefore more susceptible to neurotoxicity caused by macrocyclic lactones and other Pgp substrates due to increased drug penetration into the brain. Therefore, the safety of products containing macrocyclic lactones are required to be evaluated in this sensitive...

Read the complete abstract on PubMed

Topics

Animals
Dogs
Macrolides
Pyrantel
Dog Diseases
Praziquantel
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

ATP Binding Cassette Transporter, Subfamily B, Member 1

Tablets

Administration, Oral

Anthelmintics

Homozygote

Mutation

Drug Combinations

Oxazoles

Thiophenes

Source

Open in PubMed Open full text

Identifiers

PMID: 40269978
DOI: 10.1186/s13071-025-06795-y
PMCID: PMC12020015

Provenance

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